TB/HAART Project PDF Print E-mail

This is a multi-country study involving four countries – Tanzania, Uganda, Zambia and South Africa which started in 2006 with financial  and technical support from WHO/TDR. The purpose is to evaluate the impact of early initiation of HAART on TB treatment outcomes for TB patients co-infected with HIV. By the end of 2010, there were only 4 sites participating in the study in Dar es Salaam, Iringa, Morogoro and Tanga. However, the Morogoro and Tanga sites were stopped by the Steering Committee to  recruit new subjects because of failure to abide to good laboratory and clinical practice (GLP/GCP) standards. To mitigate the loss, the number of recruiting sites were increased from 10 to 14 (10 satellite plus 4 main sites) and the project strengthened supervision and training of staff in Dar es Salaam. The recruitment of subjects increased on average from 9 per month to 19 against a target of 25 per month. Overall, 108 new subjects were recruited and 112 were followed up in 2010.

During this period, the programme also conducted refresher training to  the entire research team to ensure that they are conversant with the guidelines and regulations governing the implementation of the study including ethical issues. In addition, 60 TB-HAART study personnel from all study sites were provided with on-job training on GLP/GCP and 20 laboratory staff from the participating sites was trained on LED FM microscopy. At the same time the project recruited three new Clinical Trial Assistants to improve follow-up of subjects recruited into the study.
Muhimbili National Hospital and the municipal hospitals in Dar es Salaam together with the regional in Iringa continued to provide satisfactory laboratory results due to improved supply of chemicals and reagents from the project and frequent supportive supervision by study coordinators. 

It is important also to report that the project lost its only car due to road accident in December, 2010 during one of its supervision missions in Morogoro. Five of the 6 people in the car received body injuries of varying degrees and two of them were admitted at Muhimbili Orthopaedic Institute for more than 2 weeks. All of them have since resumed their work.

Last Updated on Sunday, 05 August 2012 14:07